Friday, July 6, 2012

Get them some sleep, scientists say of young delinquents

Ju­ve­nile de­lin­quen­cy among high school stu­dents may be partly linked to lack of sleep, re­search­ers have found based on a new stu­dy. Al­though a handful of past stud­ies have sug­gested such a link could ex­ist, lit­tle de­tailed in­forma­t­ion ex­ists. The new anal­y­sis found that more se­ri­ous forms of de­lin­quen­cy ap­pear to be­come more com­mon in rela­t­ion to the sev­er­ity of youngsters’ sleep de­fi­cit. The study re-examined 15-year-old da­ta from the Na­tional Lon­gi­tu­di­nal Study of Ad­o­les­cent Health, a fed­er­ally funded pro­ject that sur­veyed ad­o­les­cent health in the Un­ited States in rela­t­ion to a va­ri­e­ty of risky be­hav­iors. The sur­vey sam­ple used for the study on sleep and de­lin­quen­cy en­com­passed 14,382 high school stu­dents—half ma­le, half fema­le, 63.5 pe­r­cent white. Stu­dents who slept sev­en or few­er hours nightly re­ported “sig­nif­i­cantly more prop­er­ty de­lin­quen­cy,” such as van­dal­ism or theft, than stu­dents who slept the rec­om­mended eight to 10 hours, the au­thors of the new study re­ported. The findings ap­pear in the Oct. 10 is­sue of the Jour­nal of Youth and Ad­o­les­cence. Those who slept five or few­er hours per night, meanwhile, “re­ported sig­nif­i­cantly more vi­o­lent de­lin­quen­cy,” wrote the re­search­ers, Sa­man­tha Clink­in­beard and col­leagues at the Uni­vers­ity of Ne­bras­ka at Oma­ha.
“Lack of sleep has been linked to a wide range of neg­a­tive de­vel­op­men­tal out­comes,” but “largely over­looked among re­search­ers in­ter­est­ed in ad­o­les­cent de­lin­quen­cy,” the group wrote. Al­though the study could­n’t demonstrate that in­suffi­cient snooz­ing caused de­lin­quen­cy rath­er than, for ex­am­ple, the oth­er way around, “the find­ings sug­gest that sleep is an im­por­tant, and over­looked, di­men­sion of de­lin­quent be­hav­ior,” the re­search­ers wrote. They ar­gued that this as­pect de­serves fur­ther in­ves­ti­ga­t­ion. The study did­n’t de­ter­mine wheth­er in­som­nia, home en­vi­ron­ment or oth­er fac­tors caused the sleep short­age pos­sibly linked to de­lin­quen­cy. But a smaller stu­dy, pub­lished in last De­cem­ber’s is­sue of the Jour­nal of Ge­net­ic Psy­chol­o­gy, found that “pos­sible in­som­ni­a” pre­dicted smok­ing, de­lin­quen­cy and drinking-and-driving among high school­ers. “Sleep and oth­er rel­e­vant health be­hav­iors [should] be con­sid­ered in the con­text of more com­pre­hen­sive ap­proaches to de­lin­quen­cy pre­ven­tion and in­ter­ven­tion,” Clink­in­beard and col­leagues wrote.

Tiny bugs have own personalities despite being clones, scientists say

Ti­ny green in­sects known as pea aphids have in­di­vid­ual be­hav­ior pat­terns, or “per­sonal­i­ties,” de­spite be­ing clones of one an­oth­er, sci­en­tists say. The re­search­ers found dif­fer­ences in the way each in­di­vid­ual re­sponds to a threat. The study was part of a “bur­geon­ing” of sci­en­tif­ic in­ter­est in an­i­mal per­son­al­ity varia­t­ion, not­ed the in­ves­ti­ga­tors, with the Uni­vers­ity of Os­nabrueck, Ger­ma­ny. But de­spite this trend, they added, few stud­ies have been done on in­ver­te­brates, or sim­ple an­i­mals with­out back­bones. Stud­ies on “clonal in­ver­te­brates,” which are all ge­net­ic­ally iden­ti­cal and would thus be ex­pected to show lim­it­ed dif­fer­ences in be­hav­ior, are “nonex­is­ten­t,” they added, re­port­ing their find­ings in the March 1 on­line is­sue of the jour­nal De­vel­op­men­tal Psy­cho­bi­ol­ogy. “This is sur­pris­ing giv­en the ob­vi­ous ad­van­tages of us­ing in­ver­te­brates/clones to tack­le the cru­cial ques­tion why such con­sist­ent be­hav­ioral dif­fer­ences ex­ist,” they went on. Per­son­al­ity dif­fer­ences not at­trib­ut­a­ble to genes are gen­er­ally pre­sumed to be due to the en­vi­ron­ment in which an or­gan­ism formed, though there is al­so a grow­ing ap­precia­t­ion of epige­net­ic fac­tors—chem­ical dif­fer­ences that are not ge­net­ic, but that in­flu­ence gene ac­ti­vity. Pea aphids, sci­entifically named Acyr­tho­si­phon pi­sum, are pale little in­sects ty­pi­cally less than a sixth of an inch (half a cen­ti­me­ter) long that feed on pea plants and their rel­a­tives. A clus­ter of aphids in­fest­ing a giv­en plant is typ­ic­ally a ge­net­ic­ally iden­ti­cal, or clonal, group pro­duced by one moth­er with­out sex, al­though aphids can al­so re­pro­duce sex­u­ally at cer­tain phases. When a pea aphid is threat­ened by a preda­tor—of which the spe­cies has sev­er­al in­clud­ing wasps and grub­s—it gives off a chem­i­cal alarm sig­nal that alerts near­by aphids. They may re­spond in sev­er­al ways: they can walk away, drop off the plant or seem­ingly ig­nore the sig­nal. The re­search­ers, Wiebke Schuett and col­leagues, found that pea aphids can be di­vid­ed in­to one of three cat­e­gories: con­sist­ent “drop­pers,” con­sist­ent “non-droppers,” and some that be­have un­pre­dict­a­bly.
In ex­pe­ri­ments, “ma­nipula­t­ions of early en­vi­ron­men­tal con­di­tions had lit­tle qual­i­ta­tive im­pact on such pat­terns,” the re­search­ers wrote. Al­though the rea­sons for the dif­fer­ences are un­clear, the find­ings may be im­por­tant for fu­ture stud­ies of per­son­al­ity varia­t­ion and its ev­o­lu­tion­ary and ec­o­log­i­cal con­se­quenc­es, they added. Re­search­ers seek to un­der­stand how an­i­mals de­vel­op dif­fer­ent “per­sonal­i­ties” in part be­cause they want to un­der­stand how hu­mans do so. An­i­mals are used as mod­el or­gan­isms be­cause they are of­ten sim­pler and eas­i­er to ex­pe­ri­ment on. For in­stance, an­i­mals may be bred dif­fer­ently to ex­am­ine re­sult­ing dif­fer­ences in be­hav­ior, and the early life en­vi­ron­ment of a test an­i­mal can be con­trolled and ex­am­ined. Stud­ies have found that 20 to 50 per­cent of the varia­t­ion in an­i­mal per­son­al­ity traits is ge­net­ic, ac­cord­ing to re­search­ers with the Neth­er­lands In­sti­tute of Ecol­o­gy and the Max Planck In­sti­tute for Or­nith­ol­o­gy in Ger­ma­ny, who re­viewed the sub­ject for the De­cem­ber is­sue of the jour­nal Phil­o­soph­i­cal Trans­ac­tions of the Roy­al So­ci­e­ty B. “De­vel­op­ment and learn­ing” dom­i­nate the rest of this varia­t­ion, they added. But “one of the main ques­tions that still re­mains un­re­solved is why varia­t­ion in per­son­al­ity ex­ists and how this is main­tained… Mo­lec­u­lar ge­net­ic re­search on an­i­mal per­son­al­ity is still in its in­fan­cy.”

Human ancestor ate bark, study finds

Next time you’re grum­bling about a stale cook­ie or a steak that tastes “like card­board,” count your­self lucky that you’re not Aus­tra­lo­pith­e­cus sed­iba, the hu­man an­ces­tor who ate bark. At least, that’s what sci­en­tists say about A. sed­iba, a short, gangly South Af­ri­can spe­cies from two mil­lion years ago. Their study indica­tes the crea­ture tar­geted trees, bushes and fruits for its di­et, chomp­ing on harder foods than oth­er oth­er known early ho­minids, or hu­man an­ces­tors. Vir­tu­ally all oth­ers that have been tested from Africa—in­clud­ing Paran­thro­pus boi­sei, dubbed “Nutcracker Man” thanks to its mas­sive jaws and teeth—fo­cused more on grasses and sedges, ac­cord­ing to an­thro­po­l­ogy doc­tor­al stu­dent Paul Sand­berg of the Uni­vers­ity of Col­o­rad­o Boul­der, a co-author of the new stu­dy. The find­ings were pub­lished in the June 27 on­line edi­tion of the re­search jour­nal Na­ture. Sci­en­tists an­a­lyzed the A. sed­iba di­et by zap­ping fos­sil­ized teeth with a la­ser, said Sand­berg. The la­ser breaks off tell­tale car­bon from the enam­el of teeth, so re­search­ers can pin­point which types of plants the car­bon comes from. The re­sults show which of two groups of plants were con­sumed: so-called “C3” plants like trees, shrubs and bushes pre­ferred by A. sed­iba, and “C4” plants like grasses and sedges con­sumed by many oth­er early ho­minids. The teeth from both A. sed­iba in­di­vid­u­als an­a­lyzed had lev­els of C3 out­side the range of all 81 pre­vi­ously tested ho­minids, the re­search­ers re­ported. “The lack of any C4 ev­i­dence, and the ev­i­dence for the con­sump­tion of hard ob­jects, are what make the in­ferred di­et of these in­di­vid­u­als com­pelling,” said Sand­berg. “It is an im­por­tant find­ing be­cause di­et is one of the fun­da­men­tal as­pects of an an­i­mal, one that drives its be­hav­ior and ec­o­log­i­cal niche. As en­vi­ron­ments change over time be­cause of shift­ing clima­tes, an­i­mals are gen­er­ally forced to ei­ther move or to adapt to their new sur­round­ings,” said Sand­berg.
The re­search­ers con­clud­ed that bark and oth­er “fracture-resistant” foods were at least a sea­son­al part of the A. sed­iba di­et. Some mod­ern apes and their rel­a­tives eat bark and woody tis­sues, which con­tain pro­tein and sug­ars. The di­et of A. sed­iba may have been si­m­i­lar to that of to­day’s Af­ri­can sa­van­na chim­panzees, Sand­berg said. A un­ique as­pect of the proj­ect was the anal­y­sis of mi­cro­scop­ic, fos­sil­ized par­t­i­cles of plant tis­sue known as phy­toliths trapped in an­cient tooth tarter, a hard­ened form of den­tal plaque, said study co-author Aman­da Hen­ry of the Max Planck In­sti­tute for Ev­o­lu­tion­ary An­thro­po­l­ogy in Leip­zig, Germany. “The fact that these phy­toliths are pre­served in the teeth of two-mil­lion-year-old ho­minids is re­mark­a­ble and speaks to the amaz­ing pre­serva­t­ion at the site,” said Sand­berg. “The phy­tolith da­ta sug­gest the A. sed­iba in­di­vid­u­als were avoid­ing the grasses grow­ing in open grass­lands that were abun­dant in the re­gion at the time.” A third, in­de­pend­ent line of stu­dy—analyzing mi­cro­scop­ic pits and scratch­es on A. sed­iba teeth, which re­veal what they were eat­ing short­ly before death—also con­firmed at least one of the ho­minids was eat­ing hard foods, said Sand­berg.

How tomatoes lost their flavor

Breed­ers have un­know­ingly bred the fla­vor out of toma­toes by fa­vor­ing those with a nice un­iform col­or, sci­en­tists are re­port­ing. It’s hoped the find­ing could help grow­ers re­cap­ture the old, sweet fla­vor of toma­toes—which, as they sit on su­per­mar­ket shelves to­day, of­ten seem not to taste much dif­fer­ent from the pack­ag­ing they sit in. The find­ing, re­ported in the June 29 is­sue of the jour­nal Sci­ence, could have im­plica­t­ions for the U.S. to­ma­to in­dus­try, which har­vests over 15 mil­lion tons of the fruit yearly for pro­cess­ing and fresh-market sales. “This in­forma­t­ion… pro­vides a strat­e­gy to re­cap­ture qual­ity char­ac­ter­is­tics that had been un­know­ingly bred out of mod­ern cul­ti­vat­ed toma­toes,” said Ann Pow­ell, a bio­chem­ist at the Uni­vers­ity of Cal­i­for­nia Da­vis and one of the lead au­thors of the stu­dy. For about 70 years, breed­ers have se­lected to­ma­to va­ri­eties with un­iformly light green fruit be­fore rip­en­ing. These toma­toes then turn red evenly as they rip­en, and they look nice in a su­per­mar­ket dis­play. Pow­ell and col­leagues say the gene at the heart of un­iform rip­en­ing codes for the pro­duc­tion of a mol­e­cule called GLK2, which is a tran­scrip­tion fac­tor, mean­ing it go­verns ge­net­ic ac­ti­vity.
GLK2 boosts the fruit’s ca­pa­city for pho­to­syn­the­sis, the pro­cess of con­vert­ing sun­light to sug­ars, Pow­ell and col­leagues found. The mol­e­cule al­so aids the pro­duc­tion of ly­copene, a health pro­mot­ing com­pound. But the un­iform-rip­en­ing muta­t­ion dis­ables GLK2, the re­search­ers found. This leads to in­fe­ri­or de­vel­op­ment of pho­to­syn­the­sis-enabling cel­lu­lar struc­ture called choloro­plasts, and in turn, low­er pro­duc­tion of key in­gre­di­ents that give toma­toes their sweet­ness. Re­search­ers at the uni­vers­ity be­gan stu­dying the genes in­flu­enc­ing to­ma­to de­vel­op­ment and rip­en­ing af­ter screen­ing to­ma­to plants for cer­tain tran­scrip­tion fac­tors that might play a role in both col­or and qual­ity. They were par­tic­u­larly in­ter­est­ed in toma­toes they saw that were un­usu­ally dark green be­fore rip­en­ing. Part­ner­ing with re­search­ers at Cor­nell Uni­vers­ity in New York and in Spain, who were map­ping re­gions of the to­ma­to ge­nome, the sci­en­tists disco­vered two tran­scrip­tion fac­tors, GLK1 and GLK2, that con­trol the de­vel­op­ment of chloro­plasts. The re­search­ers scoured a col­lec­tion of mu­tant and wild spe­cies of toma­toes es­tab­lished at UC Da­vis by the late Pro­fes­sor Charles Rick be­gin­ning in the 1950s. They disco­vered that dark green toma­toes that nat­u­rally pro­duce GLK2 pro­duced ripe fruit with more sug­ars or sol­u­ble solids, im­por­tant for pro­cess­ing toma­toes, as well as more ly­copene.