Thursday, August 2, 2012
A single traumatic brain injury can up Alzheimer’s risk
A single event of a moderate-to-severe traumatic brain injury can disrupt proteins that regulate an enzyme linked to Alzheimer’s disease, according to a new study. Researchers from Tufts University School of Medicine (TUSM) found that a single episode of traumatic brain injury could result in elevation of the enzyme, BACE1 in the brain. The enzyme causes elevated levels of amyloid-beta, a brain peptide whose build-up is associated with Alzheimer’s disease. “A serious TBI can lead to a dysfunction in the regulation of the enzyme BACE1. Elevations of this enzyme cause elevated levels of amyloid-beta, the key component of brain plaques associated with senility and Alzheimer’s disease,” Kendall Walker from department of neuroscience at the University, said.
posted by SCIENCE NEWS at 1:42 AM